Orthotopic Tracheal Allografts Undergo Reepithelialization With Recipient-Derived Epithelium
نویسندگان
چکیده
منابع مشابه
Role of recipient epithelium in promoting survival of orthotopic corneal allografts in mice.
PURPOSE To determine whether epithelium-deprived corneal allografts covered with syngeneic epithelium display immune privilege in orthotopic transplantation and whether syngeneic epithelium containing antigen-presenting cells nullifies this effect. METHODS Epithelium-deprived allogeneic corneas (C57BL/6) and epithelium-deprived allogeneic corneas reconstituted with syngeneic (BALB/c) epitheli...
متن کاملThe kinetics and pattern of tracheal allograft re-epithelialization.
Extensive tracheal defects may pose a life-threatening dilemma. Although tracheal transplantation may represent a reconstructive solution, very little is known regarding the immunobiology and behavior of tracheal allografts. The objective of this study was to assess the pattern and kinetics of re-epithelialization of orthotopic tracheal allografts in immunosuppressed recipients. Thirty-eight ag...
متن کاملSurvival in high-risk eyes of epithelium-deprived orthotopic corneal allografts reconstituted in vitro with syngeneic epithelium.
PURPOSE In low-risk eyes of mice, most of the composite corneal grafts composed of syngeneic epithelium layered on allogeneic stroma and endothelium are accepted indefinitely. The study was undertaken to determine the fate of similar composite corneal grafts placed in high-risk mouse eyes. METHODS Epithelium-deprived allogeneic corneas (C57BL/6) were reconstituted in vitro with BALB/c epithel...
متن کاملRecipient iNOS but Not eNOS Deficiency Reduces Luminal Narrowing in Tracheal Allografts
Chronic airway rejection is characterized by prolonged inflammation, epithelial damage, and eventual luminal obliterative bronchiolitis (OB). In cardiac allografts, the inducible nitric oxide synthase (iNOS) promotes acute rejection but paradoxically reduces neointimal formation, the hallmark of chronic rejection. The specific roles of NOS isoforms in modulating lymphocyte traffic and airway re...
متن کاملOrthotopic and heterotopic tracheal transplantation model in studying obliterative bronchiolitis.
BACKGROUND Several animal models have been established to investigate the mechanisms of obliterative bronchiolitis after lung transplantation. In this study, we compared three prevalent murine models of obliterative bronchiolitis in terms of several basic pathologic changes in a relatively short span of time after transplantation. METHODS Each of the recipient mice simultaneously received ort...
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ژورنال
عنوان ژورنال: Archives of Otolaryngology–Head & Neck Surgery
سال: 2003
ISSN: 0886-4470
DOI: 10.1001/archotol.129.1.118